Efficient Access to Arylated Aza‐ullazines by Regioselective Functionalization of their Pyridine Ring by H−Li Exchange and Electrophilic Substitution

The regioselective functionalization of aza-ullazines has been successfully realized for the first time by either metalation using BuLi-containing aggregates (BuLi-LiDMAE) or electrophilic substitution. Mono and di-bromo-derivatives were obtained in good to excellent yields further converted into aryl alkynyl azaullazine derivatives Suzuki Sonogashira cross-coupling reactions.